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Arana Arri E, Lekerika Royo N, García-Verdugo Revuelta A, Garmendia Zallo M, García De Vicuña Meléndez A, Cuesta Martín M
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Since the 1980s there has been increasing interest in invasive infections due to
Streptococcus pyogenes (the Lancefield Group A streptococci [GAS]). A number of reports
have warned of a possible resurgence of severe clinical forms of GAS infections, which
can range from uncomplicated superficial forms to severe invasive disease. Invasive GAS
infection is associated with high mortality despite early antimicrobial therapy. We present
2 such cases, one involving pneumonia and the other bacteremia with no detected
primary focus. Our aim is to draw attention to the continuing importance of GAS
infections and the use of population-based surveillance to provide data for monitoring
trends in incidence and identifying the relevance of particularly virulent strains. This
provides a rational basis for disease control measures and future vaccine development.
